Natural Pullulan Capsules® are manufactured from the raw materials of naturally fermented pullulans and a few naturally fermented ingredients. It is sourced from sucrose or starch. It is pure plant origin, no chemical and artificially synthetic substances are added, no risks of animal borne diseases, safe and healthy. The capsule is in compliance with the concept of natural and organic which people pursue. It also meets the demand of EU Clean Label and vegetarians, religious and other special people. Pullulan is inert substance, it does no harm to human being and it is not absorbed by the body. It will not burden the human body with metabolism.
The comparison of Gelatin capsules and Pullulan capsules:
| Item | Gelatin capsules | Pullulan capsules |
| Raw materials | Bovine/porcine bone or skin | Sucrose or starch |
| Chemical stability | Easy to crosslink,leading to delay the disintegrating time,reduce capsule contents dissolution,and influence pharmacological action. | Chemical inert；as well as with some healthcare function |
| Moisture content | 12.5%-17.5% | 10%-13% |
| Disintegration time | Less than 10min | 4-7min, generally,6min |
| Fragility | Less than 5 pcs in 50 pcs | None |
| Oxygen permeability | The oxygen permeability is moderate at 25℃ and 60%RH | The oxygen permeability is the lowest at 25℃ and 60%RH |
| Safety | With potential risk,especially for the emergency of TSE/BSE | Safe； fermented product |
Compared with Gelatin capsules, Pullulan capsules have some advantages as following:
- l Pure plant origin，no risk of TSE/BSE
The comparison of HPMC capsules and Pullulan capsules:
| Item | HPMC capsules | Pullulan capsules |
| Raw materials | Pine fiber | Sucrose or starch |
| Chemical stability | Chemical inert；do not be involved in the metabolized in the body. | Chemical inert；as well as with some healthcare function |
| Moisture content | 5%-8% | 10%-13% |
| Disintegration time | 4-7min, generally,6min | 4-7min, generally,6min |
| Fragility | None | None |
| Oxygen permeability | The oxygen permeability is the highest at 25℃ and 60%RH | The oxygen permeability is the lowest at 25℃ and 60%RH |
| Safety | Safe； Common used coagulants are in compliance with the pharmacopoeia of many countries. | Safe； fermented product |
Compared with HPMC capsules, Pullulan capsules have some advantages as following：
- Pure natural fermentation, no chemical substances, no maillard reaction
- No pesticide residues，non-GMO
- Low oxygen permeability, to protect the content much better
- The appearance is much brighter, high transparency
