1. High transparency.
  2. Precise weight deviation control, e.g. ±1mg, ±2mg, ±3mg, , ±4mg. Able to provide customized weight for customers.
  3. Excellent filling rate, ≥99.5%.
  4. Safe and healthy, Non-GMO, free from pesticide residue and preservative.
  5. Without any specific requirements, able to use same filling machines and moulds as gelatin capsules.
  6. Free from cross linking reaction.
Ever since its establishment in 2001, Lefancaps® has always been adhering to the concept of “Health Business First, Profit Second”, and pays more attention to serving the health industry and contributing to the community rather than purely pursuing profits. We are committed to producing safe and healthy empty hard capsules, so as to satisfy the demand of dietary supplements consumers for green, natural, healthy and organic products, in compliance with the prevailing Clean Label Concept.

With the advent of Health Era, an increasing number of consumers, especially those in Europe and the United States are more concerned than ever before with their personal health and well-being. They favour chemical-free, additive-free, and natural dietary supplements. At the same time, they demand that the ingredients are honestly and transparently described on the dietary supplement facts.

Specifically, Clean Label is described as below 3 aspects:

  • Ingredients: Natural, organic, safe, free of additives, preservatives, pesticide residues, allergen, and GMO;
  • Supplement Facts: simply, easy to understand, and all the ingredients are listed;
  • Manufacturing Process: simply process; transparent, true and trustworthy.

Lefancaps®’ Clean Label products are plant-based, free of additives, allergens, GMO, starch, and gluten as well as certified Kosher, and Vegetarian. 

  • H-caps®

H-caps ® Capsules are made from hypromellose that originates from pine tree fiber,free of GMO and residues risks. The capsules are plant-based, so it is free of potential BSE/TSE risks and crosslinking and Maillard reaction risks. Meanwhile, they are Kosher and Vegetarian verified, applicable to most consumers regardless of cultural, religious or dietary boundaries. Its low moisture content and resistance to brittle make it more suitable for moisture-sensitive or hygroscopic drugs or nutritions, like Bifidobacterium and herbal extracts.

  • Natural Pullulan Caps®

Natural Pullulan Caps® capsules are made of Pullulan and other natural ingredients through a natural fermentation process. So the capsules are natural, organic, safe, and free of additives, preservatives, pesticide residues, allergen, and GMO. At the same time, among all the plant-based capsules, Natural Pullulan Caps® capsules have excellent oxygen barrier and moisture humidity barrier properties, which can better protect the APIs and enhance the bioavaibility.

If you have any questions, please do not hesitate to contact us.  

Natural Pullulan Capsules® are manufactured from the raw materials of naturally fermented pullulans and a few naturally fermented ingredients. It is sourced from sucrose or starch. It is pure plant origin, no chemical and artificially synthetic substances are added, no risks of animal borne diseases, safe and healthy. The capsule is in compliance with the concept of natural and organic which people pursue. It also meets the demand of EU Clean Label and vegetarians, religious and other special people. Pullulan is inert substance, it does no harm to human being and it is not absorbed by the body. It will not burden the human body with metabolism.

The comparison of Gelatin capsules and Pullulan capsules:

Item

Gelatin capsules

Pullulan capsules

Raw materials

Bovine/porcine

bone or skin

Sucrose or starch

Chemical stability

Easy to crosslink,leading to delay the disintegrating time,reduce capsule contents dissolution,and influence pharmacological action.

Chemical inertas well as with some healthcare function

Moisture content

12.5%-17.5%

10%-13%

Disintegration time

Less than 10min

4-7min, generally,6min

Fragility

Less than 5 pcs in 50 pcs

None

Oxygen permeability

The oxygen permeability is moderate at 25 and 60%RH

The oxygen permeability is the lowest at 25 and 60%RH

Safety

With potential risk,especially for the emergency of TSE/BSE

Safe

fermented product

Compared with Gelatin capsules, Pullulan capsules have some advantages as following:

  • Pure plant origin,no risk of TSE/BSE
  • Good stability, no crosslink reaction
  • Do not be brittle easily
  • Low moisture content

 The comparison of HPMC capsules and Pullulan capsules:

Item

HPMC capsules

Pullulan capsules

Raw materials

Pine fiber

Sucrose or starch

Chemical stability

Chemical inertdo not be involved in the metabolized in the body.

Chemical inertas well as with some healthcare function

Moisture content

5%-8%

10%-13%

Disintegration time

4-7min, generally,6min

4-7min, generally,6min

Fragility

None

None

Oxygen permeability

The oxygen permeability is the highest at 25 and 60%RH

The oxygen permeability is the lowest at 25 and 60%RH

Safety

Safe

 Common used coagulants are in compliance with the pharmacopoeia of many countries.

Safe

fermented product

Compared with HPMC capsules, Pullulan capsules have some advantages as following:

  • Pure natural fermentation, no chemical substances, no maillard reaction
  • No pesticide residues,non-GMO
  • Low oxygen permeability, to protect the content much better
  • The appearance is much brighter, high transparency

Compared with HPMC capsules, the characters of Pullulan capsules are more like Gelatin capsules. The only defect is that the production of Pullulan capsules is low at present, the cost is high, and the price is on high side. However, as the technology matures, with the increase of quantity, the cost will decrease correspondingly, Pullulan capsules are expected to be cheaper than HPMC capsules in the future.

I have visited several supplement factories in the United States and found an interesting phenomenon: Some of dietary supplement manufacturers actually weigh filled capsules by using a 100g by 0.01g (10mg) Electron balance, weighing 10 capsules and calculating the average mass.

However, in USP Chapter 41: “Balances”, it states the requirements of repeatability and accuracy for balances used for materials as follows:

  • The repeatability is satisfactory if 2 × 0.41d, divided by the desired smallest weight does not exceed 0.10%.
  • The accuracy of a balance is satisfactory if its weighing value, when tested with a suitable weight(s), is within 0.10% of the test weight value.

Based on the requirements and capsule weight unit“mg”, at least, a precision balance with accuracy of 0.001g (1mg) shall be used to weigh capsules.

Lefancaps® believes accurate weight and scientific dose are significant for the effect of drugs and nutrition. If the weight is inaccurate, it will not only affect the therapy effect, hinder the disease from getting better, and bring sufferings to patients, but also cause medical malpractice, even cause death in patients. Scientific methods and appropriate measuring instruments are necessary to meet the requirements of accurate and reliable weighing. In that way, how to choose the appropriate balance to guarantee the accuracy of capsule dosage and weight variation?

  • Electron Balance Classification

Type

Electron Balance

Number of digits after decimal position (g)

Accuracy Class

1

Ultra-Micro Balance

7

I

2

Mirco Balance

6

I

3

Semi-micro Balance

5

I

4

Analytical Balance

4

I

5

Precision Balance

3

II

6

Technical Balance

0 to 1

III

 

  • Lefancaps® Special Offering for Weight Variation Control
  1. Lefancaps® provides stable capsule manufacturing technology to guarantee each capsule weight is precisely controlled within the specification range;
  2. Lefancaps® has capsule inspection machines which position the capsules more accurately and auto wipe out the unqualified capsules beyond the weight range;
  3. Lefancaps® provides full-auto weight screening machine to accurately weigh each capsule and automatically select the qualified capsules based on pre-set qualified weight range;
  4. Lefancaps® provides electron balances with 1mg /0.1mg/0.01mg accuracy to satisfy consumers’customized weighing requirements.
  • Drugs & Nutrition Application Guide on Weighing Accurately
  1. Drugs: Applicable to Narrow therapeutic index (NTI) drugs, rescue medicines, drugs for the following people: babies, children, pregnant or breast feeding women, people with chronic patients, etc.
  2. Nutrition: Applicable to western nutrition, including but not limited to diet caps, antidiabetic caps, anti-fatigue caps, immunotherapy caps, sleep aid caps hypotensive drugs.